A 55-year-old male presented to the emergency room with sudden and severe abdominal pain, subsequently diagnosed as acute pancreatitis. The patient was managed conservatively in the critical care unit. On the first day, he developed fever, and liver function tests (LFTs) indicated a cholestatic pattern. Aggressive treatment commenced, including higher antibiotics and ursodeoxycholic acid (UDCA). However, minimal improvement was observed in LFTs on the second day. Further investigations revealed choledocholithiasis with gallbladder calculi on magnetic resonance cholangiopancreatography (MRCP). Inflammatory markers such as C-reactive protein (CRP) and procalcitonin were significantly elevated. Urgent endoscopic retrograde cholangiopancreatography (ERCP) with stone removal and biliary stent deployment was performed, leading to a smooth recovery.